Originally founded in 2013 with technology spun out of the Weizmann Institute of Science, miCure leverages its deep understanding of the role of microRNAs in the biology of psychiatric diseases. More recently, the company has expanded its scientific and technological scope to include neurodegenerative and neurologic diseases, as well as other classes of RNAi therapeutics and novel methods to deliver oligonucleotides to the CNS.
mir-135 is a key modulator of depression and anxiety in numerous animal models
Selective
No reduction of post-synaptic HTR1A
Biologic effect
Serotonin brain levels increase
Technology
Non-invasive brain delivery
Dual activity
Modulates both Serotonin transporter and HTR1a auto receptor
Precision medicine
Ability to target specific neurons in the dorsal raphe nucleus
High profile
Immunologically safe
Technology
Proprietary non-invasive oligonucleotide brain delivery technology. It allows precise delivery of siRNA, miRNA and ASOs to modulate gene expression in specific cells.
The technology consists of linking the oligonucleotide of interest to a small molecule ligand that binds to neurotransmitter transporters or GPCR receptors.
Pre-clinical data in rodent and non-human primate models, including proof-of-concept studies showing viability of intranasal (“nose-to-brain”) administration of oligonucleotide conjugates
We use cookies to optimize our website and our service.
Funcional
Siempre activo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferencias
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Estadísticas
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.