Spun out of Weizmann institute for Science in 2013, the company utilize RNA interference technology based on the robust scientific discoveries where a deep understanding of the biology behind microRNAs involvement in central nervous system (CNS) related disorders, was gained.
which was demonstrated to act as a key modulator of depression and anxiety in numerous models
No reduction of post-synaptic HTR1A
Serotonin increase in the brain
Non-invasive brain delivery
Modulates both Serotonin transporter and serotonin auto receptor
With neuron targeting specifically in the dorsal raphe nucleolus
miCure owns a technology of a non-invasive brain delivery of oligonucleotides like siRNAs, miRNAs and ASOs that allows targeting gene expression modulation in specific cell types (pathology related population). The technology is based on linking the oligonucleotide of interest to a ligand of a neurotransmitter transporter and was demonstrated to be effective in NHP studies.